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Fang LuPHONE NUMBER AVAILABLE (Cell) EMAIL AVAILABLEPROFILEAn innovative, result/quality-oriented and self-motivated researcher with (1) more than 15 years of biotech industry experiences in genetics, genomics, molecular biology and statistics; (2) proven expertise in gene expression and characterization, SNP marker discovery/assay development/implementation, DNA fingerprinting and high throughput genotyping, genetic diversity analysis, Next Generation Sequencing (NGS), genome editing, cell culture, lab automation/LIMS and Six Sigma; (3) strong skills in project, lab, research assistant management; (4) exceptional organizational/problem-solving skills and ability to manage multiple tasks/priorities, and (5) proven ability to work well independently as well as in teams.LAB TECHNIQUES AND AUTOMATIONLife Technologies TaqMan Assay design DNA, RNA and Protein Extraction, Purification and Quantification PCR Primer Design Bio Rad Digital Droplet PCR, RT-PCR, qPCR, qRT-PCR, RACE-PCR, TAIL-PCR, Multiplex-PCR and Long-Distance PCR Reverse Transcription TA Cloning Sanger Sequencing and SSR Genotyping (ABI3730) Illumina Infinium/GoldenGate SNP array Next Generation Sequencing (illumina, PacBio) KBioscience KASPar and Invader SNP Genotyping DNA Fingerprinting Fluidigm PCR and Genotyping Gene Cloning and Gene Expression Vector Construction and Gene Transformation Transgenic Event Characterization and Zygosity Analysis Mammalian Cell Culture and Transfection Cell Line Development Luciferase Assay Crossing and Population Development SDS-PAGE Western Blot Southern Blot Northern Blot Confocal Fluorescence Microscopy Lab Automation/LIMSDATA ANALYSISqPCR Quantification data analysis Molecular Marker Discovery/Assay Development/Validation Genetic Diversity and Phylogenetic Analysis Genotypic Data Analysis Genetic Analysis Statistical Analysis Genetic and Consensus Map Construction Marker-Assisted Selection (MAS)/Backcrossing (MABC) Genetic/QTL/Association Mapping Haplotype Analysis Trait Discovery/Characterization/Introgression/ Conversion/Integration Bulked Segregated Analysis Germplasm Characterization and Seed Purity QA/QC Bioinformatics and Sequence Data Analysis (Alignment, Assembly and Annotation) Proteomics Data Analysis Microarray Data Analysis Experimental Design Six Sigma MethodologyCOMPUTER PROGRAMMING AND SOFTWARE APPLICATIONScientific Software: Vector NTI Suite, Geneious, DNA star, Primer Express, Genome Studio, Kraken, Array Studio, BioEdit, GBrowser, JMP, JMP Genomics, TIBCO Spotfire, Tableau, Mapmaker, JoinMap, etc.Office Software: Microsoft Office (Word, Excel, PowerPoint, Outlook, Team), Photoshop and Acrobat, Endnote Programing: Familiar with SAS, R, SQL, C, Java, Perl, Python, Unix, Mac OS and HTMLPROFESSIONAL EXPERIENCEFlagship Biosciences, Morrisville, NC USA 2023 - 2024ScientistLed NGS assay development and evaluation in a CLIA labPfizer, Cambridge, MA USA 2020 - 2023Scientist in Rare Disease Research Unit (RDRU)Support novel cardio gene therapy research by designing and validation assays for transgene and endogenous gene-of-interest quantifications on nucleic acids and protein, including ddPCR TaqMan assay design, NGS, cloning, iPSC cell culture, and Jess Simple WesternLed gene therapy titer assay design and evaluation to support gene therapy research productionAmgen, Thousand Oaks, CA, USA 2015 - 2020Associate Scientist in Pre-Pivotal Drug Substance Technologies (PD)Led more than 25 drug substance and products genetic stability analysis to support drug products FDA filing for clinical trial studyScreened & characterized drugs genetic variants to support clone selection in cell line developmentQuantified gene expressions at different stages to support pre-pivotal bio-process developmentDrafted the BLA 3.2.S.3.2 session, IND FDA filing and participated in the regulatory review meetingsApplied high throughput assay platforms, lab automation facilities, and next generation sequencing bioinformatics to support lab technology developmentDOW AGROSCIENCES, Indianapolis, IN, USA 2008 - 2015Lead Molecular Biologist in Trait Genomics and Technologies (TG&T)Led soybean genome-wide SNP marker discovery, validation and mapping. Identified 6.8 million putative SNPs through NGS, public database and external collaboration, validated 76K+ SNPs, and constructed high density maps with 30K+ soybean SNP markers through Illumina Infinium/GoldenGate, BioTrove OpenArray, TaqMan, KASPar genotyping technologies and genotyping by sequencing (GBS).Selected 12,000 SNP markers, and developed a 12K production Infinium Chip for routine soybean germplasm characterization, trait/QTL/association mapping, marker-assisted selection (MAS) and marker-assisted backcrossing (MABC), genome wide association study (GWAS), heterosis prediction and genomic selection (GS).Led genetic mapping and marker development of soybean Phytophthora and SCN resistance traits.Coordinated and performed lab works and data analyses, and mapped 10+ soybean traits (Root Knot Nematode, Brown Stem Rot, Frogeye Leaf Spot, White Mold, Sudden Death Syndrome, Rsv4, Charcoal Rot, Fe Deficiency, Early Flowering, Apomixes, Aphid Resistance, Insect Attractiveness, CMS and Rf), for MAS and trait introgression/stacking/integration.Performed soybean genetic diversity analyses, and helped the breeders to better characterize and utilize the soybean cultivars and germplasm.Worked with breeders, MABL, HTMA and informatics team, and streamlined soybean material storage and genetic/genomic/genotypic data storage for easy track and utilization.Participated in the canola, cotton and maize genome-wide and trait-associated marker development.Characterized zinc-finger nuclease (ZFN) induced transgenic events in canola through NGS.Worked with other function teams, and fine mapped and cloned two maize fertility restorer genes.Developed quantitative PCR assays to quantify cotton reniform nematode infection.Prepared sequencing libraries for Illumina NGS platforms.Trained and supervised research associate, assistants, contractors and interns in lab work and safety.Served as the focal point for JMP Genomics training and applications.Documented 40 SAGEs (company research reports) and 14 Invention Disclosure Memorandums (IDMs), including nine patents submitted and two granted.UNIVERSITY OF GEORGIA, Athens, GA, USA 2004 - 2009Graduate Research Assistant in Genetics and Statistics, Department of Genetics (2006 - 2009)Studied the nature and consequence of chromosomal double-strand break (DSB) repair in maize, rice, and sorghum by transformation of yeast gene I-Sce I and its targeted sequence (Thesis research).Made crosses and developed populations in maize, rice, and sorghum.Performed metagenomic study on interactions between soil microbes and plant roots.Gained four years of experiences in genetic and genomics, especially in vector construction/gene cloning, gene transformation and event characterization, gene expression, DNA/RNA extraction, high-throughput genotyping, sequencing and sequence data analyses (alignment, assembly and annotation).Performed statistical analysis of microarray data from a comparative genomic study of Campylobacter jejuni.Graduate Research Assistant in Obesity Physiology, Department of Animal & Dairy Sciences (2004 - 2005)Investigated the inhibitory effects of leptin on mouse/rat adipogenesis in vitro (3T3-L1 cell) and in vivo.Studied the relationship between adipocyte accumulation and bone marrow cell growth.Measured the DNA degradation in adipocyte cells due to apoptosis.Assisted lab manager in routine lab maintenance jobs (e.g. mouse husbandry and tissue collection, mammalian cell line maintenance and culture, reagent preparation and basic molecular experiments).EDUCATIONUNIVERSITY OF GEORGIA, Athens, GA, USA (Average GPA 3.74)M.Sc. in Genetics (May/2009; GPA 3.81/4.0; Department of Genetics; Advisor: Professor Jeffrey L. Bennetzen)Thesis: Comparative Genomic Study of Chromosomal Double-Strand Break Repair in Maize and RiceM.Sc. in Statistics (August/2008; GPA 3.68/4.0; Department of Statistics)Consulting Project: Statistical Analysis of Microarray Data from a Comparative Genomic Study ofCampylobacter jejuniCertificate in DAT208x: Introduction to Python for Data Science by Microsoft on EdxCertificate on Data Science, a 10-course Specialization by Johns Hopkins University on Coursera: Data Science Capstone Developing Data Products Practical Machine Learning Statistical Inference Reproducible Research Exploratory Data Analysis Regression Models Getting and Cleaning Data R Programming The Data Scientists ToolboxOREGON STATE OF UNIVERSITY, Corvallis, OR, USAStudied Courses (C Language, Java Programming, Data Structures, Unix Operating System, Digital Logic Design, Theory of Computation, and Algorithms Analysis) in Computer ScienceSELECTED COURSEWORKAdvanced Biochemistry & Molecular Biology (I, II) Advanced Topics in Biochemistry and Molecular Biology Nucleic Acids Plant Genetics Advanced Molecular Genetics Advanced Genetics Seminar Genome Analysis Genomics and Bioinformatics Population Evolution & Molecular Genetics Advanced Evolutionary Biology Immunology Mammalian Physiology Statistical Methods (I, II) Mathematical Statistics (I, II) Linear Models Nonparametrics Multivariate Methods Sampling Methods Experimental Designs Clinical Trials Computational Methods SAS Programming C Programming Java Programming Data StructuresPATENTS GRANTEDYonghe Bai, Fang Lu, Thomas Greene, Robert E. Moore, Jr., Bradley Hedges, Siva Kumpatla, and RaghavRam (2010) Soybean markers linked to SCN resistance (Publication number: WOPHONE NUMBER AVAILABLE A2)Yonghe Bai, Fang Lu, Tyler Mansfield, Jenelle Meyer, Robert E Moore, Jr., Bradley Hedges, William M.Campbell, Juju Manandhar, Jan E.Backlund, David H. Meyer, Siva Kumpatla, and Raghav Ram (2013) Soybean markers linked to Phytophthora resistance (Publication number: US PHONE NUMBER AVAILABLE A1)PUBLICATIONSNatalia Gomez, Agatha Wieczorek, Fang Lu, Richele Bruno, Luis Diaz, Neeraj J. Agrawal, Kristi Daris (2018) Culture temperature modulates half antibody and aggregate formation in a Chinese hamster ovary cell line expressing a bispecific antibody. Biotechnology and BioengineeringTharmala Tharmalingam, Hedieh Barkhordarian, Nicole Tejeda, Kristi Daris, Sam Yaghmour, Pheng Yam, Fang Lu, Chetan Goudar, Trent Munro, Jennitte Stevens (2018) Characterization of phenotypic and genotypic diversity in subclones derived from a clonal cell line. Biotechnology ProgressGunvant Patil, Tri D. Vuong, Sandip Kale, Babu Valliyodan, Rupesh Deshmukh, Chengsong Zhu, Xiaolei Wu, Yonghe Bai, Dennis Yungbluth, Fang Lu, Siva Kumpatla, J. Grover Shannon, Rajeev K. Varshney, Henry T Nguyen (2018) Dissecting genomic hotspots underlying seed protein, oil, and sucrose content in an interspecific mapping population of soybean using high-density linkage mapping. Plant Biotechnology JournalAparna Deshpande, Ana Clara Pontaroli, Srinivasa Chaluvadi, Fang Lu, and Jeffrey L. Bennetzen (2011) Plant genetics for study of the roles of root exudates and microbes in the soil. In: Antonio Costa de Oliveira and Rajeev K. Varshney (Eds.) Root Genomics. Springer ISBN: 978-3-540-85545-3, 280 pages.AWARDSAchievement in Crop Genetic and Technology (ACGT) Award, Dow AgroSciences LLC 2009, 2010, 2013Innovators Day Award, Dow AgroSciences LLC 2009, 2010, 2011, 2012, 2013, 2014Graduate School Fellowship at University Georgia 2004-2006