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Click here or scroll down to respond to this candidatePage 1 of 3Bin (Esther) Jiang, PhDPHONE NUMBER AVAILABLE EMAIL AVAILABLELinkedIn LINKEDIN LINK AVAILABLESUPERVISOR / SCIENTIST / LEADOF CLINICAL MOLECULAR LABOROTARYHighly accomplished professional with Senior-level NGS, genetic, genomic, forensic testing, R&D, and management skills with proven ability to develop, lead and achieve organizational goals in a team-oriented environment. Doctorate in Forensic Medicine with extensive experience setting up and running forensic and genetic testing laboratories. Proven record of devising and executing clinical testing methodologies resulting in successful and effective results used by a wide variety of health care professionals and customers from other fields. Technical Skills: Python, R, SQL, Excel, Power BI, VBA, Cloud Computing, AWS. CORE SKILLSClinical Molecular Lab R&D NGS DNA Sequencing qPCR dd-PCR CGH Micro Array MLPA Genetic/Genomic Data Analysis Variant Curation Bioinformatics DNA Fragment Analysis LDT IVD validation Management Clinical Medicine Knowledge Cell Biology Pathology Internal/External Auditing Led successfully in establishing clinical molecular labs and conducting of various molecular and NGS panel develop and validation in germline disease/tumor and somatic tumor using Illumina platform and a variety of variant curation and interpretation platforms for clinical genome sequencing, exome sequencing, NGS panel, and single gene tests using different online databases and tools. Directed in streamline the daily workflow in combination of different kinds of bioinformatics data analysis pipelines, such as Agilent Alissa, FrankLin, SOPHiA, etc by using different links of technical skills. Effectively reported to director(s) and cooperated and communicated with different internal, cross-functional projects and external teams or groups to troubleshoot and provide specific expert opinions on NGS products, variants, genes, and clinical findings to customers or patients. Demonstrated and testified skillful management and leadership ability both in an academic and industrial environments. Worked with top academic institutions, telemedicine services, medical researchers, and engineers to translate breakthrough findings into novel clinical tests. Understood and articulated complex scientific, interpersonal, regulatory, and business issues. Led efforts to establish testing and reporting regimes to obtain licensing and certification in a variety of areas. Developed and conducted testing regimes and analyses and workload processes to improve testing accuracy, identify variants, and procure diverse testing menu and clientele. Led the entire accreditation process (ISO/IEC 17025/15189 certification/CLIA) for forensic/genetic and genomic testing. Founded 3 Institutes, one of the first forensic testing laboratories in China. Bin (Esther) Jiang, PhDPHONE NUMBER AVAILABLE EMAIL AVAILABLELinkedIn LINKEDIN LINK AVAILABLEPage 2 of 3PROFESSIONAL EXPERIENCEMolecular Lab SupervisorQUADRANT LABORATORIES Syracuse, New York Jan 2024 Present Designed and directed assay R&D and validation (NGS, qPCR, dd-PCR, MLPA, CGH-array, etc.) Designed and developed a novel 285-gene ASD-XLID NGS panel according to CLIA standard and other related regulatory requirements and passed the validation of NYSDOH. Direct and supervise the NGS lab and molecular lab, which include but not limited to DNA/RNA isolation, DNA QC, PCR, library preparation, library quantification and sequencing on various platforms as Illumina, Agilent, Bio-Rad, ABI, NGS, Sanger sequencing, Bio-Rad qPCR and dd-PCR platforms and their related analysis methods and software. Design and develop the bioinformatics of 285-gene targeted NGS panel. Design and develop the pipeline of interpreting sequencing quality data, interpret/annotate/variant curate genetic and genomic data on 285-gene ASD-panel and Fragile-X. Designed and cooperated and interacted with BI team, bench team, management team, IT team and outside teams to execute and analyze genomic data. Work closely with the directors and other groups or teams to discuss in report preparation, data annotations, data explanation.Senior ScientistACUTIS DIAGNOSTICS Monmouth Junction, New Jersey Jan 2023 Dec 2023 Successfully Led teams in validate/implement targeted Illumina TSO500 NGS tests for FFPE solid tumor and TrueSight_HC_Panel for germline diseases. PGx assay development, validation, qualification, and implementation using qPCR methodology. SME for analytical methods, testing and validation protocols, and standard operating procedures (SOPs) Evaluated and implemented assay QC parameters applicable to NGS and applied correct assay orthogonal testing and implemented applicable reference materials. Developed assays and designed corresponding reporting format, produced assay validation reports, and delivered report presentations to senior management and project teams. Performed clinical sample testing post-assay validation and developed QA review to establish CAPA(corrective action/preventative action) plan. Established laboratory safety protocols in compliance with Federal, State, and local regulatory requirements. Trained project teams/scientist in testing methodologies and data analysis. Senior Clinical Genetic and Genomic Data Scientist SEMA4 Stamford, Connecticut May 2019 Jan 2023 Established/conducted data analyses for broad genetic testing menu, including WHS, WES, targeted panels. Provided clinical genetic and genomic data analysis, variant curation and other interpretation using different gene data analysis software and online data sources and tools with observance of ACMG/AMP guidelines. Supervised laboratory bench work and QA.Bin (Esther) Jiang, PhDPHONE NUMBER AVAILABLE EMAIL AVAILABLELinkedIn LINKEDIN LINK AVAILABLEPage 3 of 3 Designed/Established/implemented laboratory-wide data review and interpretation processes of genomic test results, resulting in productivity gains and tripling of case volume analyses (4,000 to 12,000 annually) Automated daily processes using Python, R, Excel, VBA, etc., to increase efficiency, efficacy, and accuracy. Director & PrincipalSOJIANGER LLC Great Neck, New York Jan 2016 Apr 2019 Developed workflow routines to increase productivity and efficiency using Python, R, SQL, Excel, Power BI, Microsoft VBA, and other productivity/efficiency tools. Provided clinical genetic/genomic data analyses/interpretation services. External auditor for ISO 17025 laboratories, consultant with CLIA laboratory regulations and processes Senior DirectorBIOSTAR FORENSIC GENETIC EXPERTISE INSTITUTE Shanghai, China Jun 2006 Dec 2015 Founded the Institute, one of the first forensic testing laboratories in China. Led the accreditation process (ISO/IEC 17025/15189 certification and CLIA) for forensic/genetic testing. Supervised production workflow and established procedures and protocols for efficiency/efficacy/safety. Managed R&D Team leading DNA polymorphism research programs using chip technology. Developed and oversaw Quality Assurance (QA) and Quality Control (QC) programs and administered laboratory training. Accomplished thousands of forensic paternity, individual identification, and forensic pathology cases. Built out lab to level of 1000+ cases/year with business from prosecutorial entities and court testimony. Established testing/safety protocols, data analysis tools/procedures, and reporting formats/training regimes EDUCATION (ECE and WES accredited. Eligibility for ASCP) Ph.D. (with honors) in Forensic MedicineSUN YAT-SEN UNIVERSITY, SCHOOL OF MEDICINE, Guangzhou, China Masters Degree in Tumor PathologyUNIVERSITY OF SOUTH CHINA, SCHOOL OF MEDICINE, Hunan, China B.S., Clinical Medicine (MD)UNIVERSITY OF SOUTH CHINA, Hunan, China |
