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April 2024CURRICULUM VITAEName:XINZHI RICHARD CHEN, MD, PhD, MSN, MSc, BSNBusiness Address:University of PittsburghSchool of Nursing318A Victoria Building3500 Victoria StreetPittsburgh, PA 15261Email Address:EMAIL AVAILABLEBusiness Phone:PHONE NUMBER AVAILABLEBusiness Fax:PHONE NUMBER AVAILABLEEducation and TrainingUndergraduate1992-1997Dalian Medical University, Dalian, P.R. ChinaM.D. equivalentMedicine2016-2017Duquesne University School of Nursing, Pittsburgh, PA, USABSN NursingGraduate2000-2003Dalian Medical University, Dalian, P.R. ChinaM.Sc.Public Health (Biochem-Toxicology)2004-2009University of Wisconsin-Madison, Madison, WI USAPh.D.Neuroscience2017-2020Duquesne University School of Nursing, Pittsburgh, PA USAMSNNursing EducationPostgraduate2009-2012National Institute of Aging, NIH, Baltimore, MD USANeuroscienceAppointments and PositionsAcademic2023 to presentUniversity of Pittsburgh School of NursingDepartment of Acute & Tertiary Care, Pittsburgh, PA USAAssistant Professor2021 to 2023Misericordia University, Nursing Department ABSN, Coraopolis, PA USAAssistant professor2016 to 2021Duquesne University School of Nursing, Pittsburgh, PA USAAdjunct faculty2013 to 2015University of Pittsburgh, School of MedicineDepartment of Neurology, Pittsburgh, PA USAResearch Associate2009-2012BioVisions, Inc. /National institute of Aging, NIHBaltimore, MD USAResearch Scientist /postdoc fellow2004 to 2009University of Wisconsin-Madison, School of MedicineDepartment of Neurological Surgery, Madison, WI USAResearch Assistant2005University of Wisconsin-Madison, School of MedicineDepartment of Zoology Madison, WI USATeaching Assistant1997 to 2004Dalian Medical University,Department of Public Health Dalian, P.R. ChinaAssistant Professor/ Instructor (Primary)1997 to 2003Sino-Japanese Cooperation Medicament Science Research Institute, Dalian, P.R. ChinaScientist (Secondary)Non-Academic2016-presentSteel City interpreters, Pittsburgh, PA USAProfessional Medical Interpreter (Mandarin)2016-2021University of Pittsburgh Medical CenterMontefiore Hospital, Pittsburgh, PA USASenior Professional staff Nurse1996-1997The First Affiliated Hospital of Dalian Medical University, Dalian, P.R. ChinaMedical InternCertification and Licensure2016 to presentPennsylvania State Board of Nursing, RN6897132016 to presentAmerican Heart Association, Basic Cardiac Life SupportMembership in Professional and Scientific Societies2021- presentAmerican Nurses Association/Pennsylvania State Nurses AssociationMember2010-2015Sigma XiMember2006- 2018Society for NeuroscienceMember1997-2003Toxicology Professional Committee of Dalian Preventive Medicine, Dalian, P.R. ChinaBoard member1997-2003Advanced teaching professionals, Dalian, P.R. ChinaBoard memberHonors1992-1997Excellent Student Scholarship, Dalian Medical University, Dalian, P.R. China1997Excellent grad student of Liaoning province (State level), the Educational Committee of Liaoning, P.R. China2007 & 2008Vilas travel grant award, University of Wisconsin-Madison, Madison, WI USAPublicationsRefereed Articles * = Data Based;  = Senior Author;1.Chen, X., Hong, X., Chen, Z., Lu, Y., Zhong, L. (2000). Effects of epidermal growth factor on morphology and MTT reduction of Hela cells. Journal of Dalian Medical University. 3:179-181.2.Chen, X., Lu, Y., Hong, X., Ye, J., Song, S., Zhong, L. (2000). The preventive effects of meglumine observed on the cisplatin-induced nephrotoxicity. Journal of Dalian Medical University. 4: 249-253.3.Chen, X., Lu, Y., Hong, X., Ye, J., Guan, Y., Zhong, L. (2000). The preventive effects of meglumine on nephrotoxicity induced by cisplatin. Journal of Health Toxicology. 4: 714.Zhong, L., Chen, X., Lu, Y., Nan, H. (2001). The preventive effects of flavanols on Rats nephrotoxicity induced by cisplatin. Journal of Health Toxicology. 2: 545.Chen, X., Lu, Y., Hong, X., Guan, Y., Zhong, L. (2002). The preventive effects of meglumine on Rats nephrotoxicity induced by cisplatin and discussion on its mechanism. Journal of China Public Heath. 1:53-54.6.Lu, Y., Li, Q., Chen, X., Liu, X., Ye, J., Song, S., Zhong, L. (2002). Protective effects of glutathione on cisplatin-induced toxicity to primary cultured rat renal tubular epithelial cells without sex-dependent difference. Journal of Dalian Medical University. 4: 244-246.7.Lu, Y., Li, Q., Gong, D., Dai, Z., Chen, X., Song, S., Zhong, L. (2003). The use of primary cell cultures to test drug-induced short-term toxicity. Journal of Health Toxicology. 17(2):12-114.8.Hong, X., Chen, X., Ye, J., Liu, X., Li, Q.,Song, S. Zhong, L. (2003). Inhibitory effect of cisplatin on proteasome. Journal of Health Toxicology. 17 (2): 84-86.9.Li, H., Chen, X., Zhong, L. (2003). Preventive effects of flavones on nephrotoxicity of cisplatin in Rats. Journal of Shenyang medical college. 5 (2): 109-111.10.Lu, Y., Chen, X., Zhong, L. (2003). Renal glutathione system and its toxicological significance. Journal of Environmental Hygiene. 30 (5): 274-278.11.Chen, X., Hong, X., Li, H., Lu, Y., Du, B., Zhong, L. (2003). Establishment of over-expressing ERCC1 protein cell line. Journal of Dalian Medical University. 25 (3): 163-168.12.* Wang, H., Lian, H., Xu, J., Li, H., Chen, X. (2003). The preventive effects of silibinin on the cardiac toxicity caused by doxorubicin. Adverse Drug Reactions Journal. 6 (5): 371-374.13.Lu, Y., Li, Y., Du, B., Chen, X., Zhong, L. (2004). Decrease in accumulation of platinum in cisplatin treated HEK293 cells caused by non-protein sulfhydryl. Journal of Health Toxicology. 18 (3): 167-168.14.Li, H., Chen, X., Zhong, L. (2005). Study on DNA damage induced by aristolochic acid in vitro. Journal of Health Toxicology. 19 (4): 290-292.15.Du, B., Jiang, L., Xia, Q, Lu, Y. Chen, X., Zhong, L. (2006). The synergistic anti-proliferative effect of curcumin and fluorouracil on human colon cancer cell line HT-29. Acta Nutriment Sinica. (1): 75-79.16.Adibhatla, R. M., Hatcher, J. F., Larsen, E. C., Chen, X., Sun, D., & Tsao, F. H. (2006). CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke. J Biol Chem, 281(10), 6718-6725. https://doi.org/10.1074/jbc.M51211220017.Luo, J., Wang, Y., Chen, X., Chen, H., Kintner, D. B., Shull, G. E., Philipson, K. D., & Sun, D. (2007). Increased tolerance to ischemic neuronal damage by knockdown of Na+-Ca2+ exchanger isoform 1. Ann N Y Acad Sci, 1099, 292-305 https://doi.org/10.1196/annals.1387.01618.Luo, J., Wang, Y., Chen, H., Kintner, D. B., Cramer, S. W., Gerdts, J. K., Chen, X., Shull, G. E., Philipson, K. D., & Sun, D. (2008). A concerted role of Na+ -K+ -Cl- cotransporter and Na+/Ca2+ exchanger in ischemic damage. J Cereb Blood Flow Metab, 28(4), 737-746. https://doi.org/10.1038/sj.jcbfm.960056119.Wang, Y., Luo, J., Chen, X., Chen, H., Cramer, S. W., & Sun, D. (2008). Gene inactivation of Na+/H+ exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemia. Eur J Neurosci, 28(1), 51-61. https://doi.org/10.1111/j.1460-9568.2008.06304.x20.Chen, X., Kintner, D. B., Luo, J., Baba, A., Matsuda, T., & Sun, D. (2008). Endoplasmic reticulum Ca2+ dysregulation and endoplasmic reticulum stress following in vitro neuronal ischemia: role of Na+-K+-Cl- cotransporter. J Neurochem, 106(4), 1563-1576. https://doi.org/10.1111/j.1471-4159.2008.05501.x21.Liu, Y., Kintner, D. B., Chanana, V., Algharabli, J., Chen, X., Gao, Y., Chen, J., Ferrazzano, P., Olson, J. K., & Sun, D. (2010). Activation of microglia depends on Na+/H+ exchange-mediated H+ homeostasis. J Neurosci, 30(45), 15210-15220. https://doi.org/10.1523/JNEUROSCI.3950-10.201022.Kintner, D. B., Chen, X., Currie, J., Chanana, V., Ferrazzano, P., Baba, A., Matsuda, T., Cohen, M., Orlowski, J., Chiu, S. Y., Taunton, J., & Sun, D. (2010). Excessive Na+/H+ exchange in disruption of dendritic Na+ and Ca2+ homeostasis and mitochondrial dysfunction following in vitro ischemia. J Biol Chem, 285(45), 35155-35168. https://doi.org/10.1074/jbc.M110.10121223.Chen X*, Vitzthum, L*., Kintner, D. B., Huang, Y., Chiu, S. Y., Williams, J., & Sun, D. (2010). Study of Na+/H+ exchange-mediated pHi regulations in neuronal soma and neurites in compartmentalized microfluidic devices. *Contribute equally. Integr Biol (Camb), 2(1), 58-64. https://doi.org/10.1039/b918440f24.Chen, X., Kintner, D. B., Baba, A., Matsuda, T., Shull, G. E., & Sun, D. (2010). Protein aggregation in neurons following OGD: a role for Na+ and Ca2+ ionic dysregulation. J Neurochem, 112(1), 173-182. https://doi.org/10.1111/j.1471-4159.2009.06438.x25.Ferrazzano, P., Shi, Y., Manhas, N., Wang, Y., Hutchinson, B., Chen, X., Chanana, V., Gerdts, J., Meyerand, M. E., & Sun, D. (2011). Inhibiting the Na+/H+ exchanger reduces reperfusion injury: a small animal MRI study. Front Biosci (Elite Ed), 3(1), 81-88. https://doi.org/10.2741/e22226.Liu, D., Pitta, M., Jiang, H., Lee, J. H., Zhang, G., Chen, X., Kawamoto, E. M., & Mattson, M. P. (2013). Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession. Neurobiol Aging, 34(6), 1564-1580. https://doi.org/10.1016/j.neurobiolaging.2012.11.02027.Jing, Z., Xing, J., Chen, X., Stetler, R. A., Weng, Z., Gan, Y., Zhang, F., Gao, Y., Chen, J., Leak, R. K., & Cao, G. (2014). Neuronal NAMPT is released after cerebral ischemia and protects against white matter injury. J Cereb Blood Flow Metab, 34(10), 1613-1621. https://doi.org/10.1038/jcbfm.2014.11928.Chen, X., Arumugam, T. V., Cheng, Y. L., Lee, J. H., Chigurupati, S., Mattson, M. P., & Basta, M. (2018). Combination Therapy with Low-Dose IVIG and a C1-esterase Inhibitor Ameliorates Brain Damage and Functional Deficits in Experimental Ischemic Stroke. Neuromolecular Med, 20(1), 63-72. https://doi.org/10.1007/s12017-017-8474-6Published Abstracts1.Adibhatla, R.M., Hatcher, J.F., Larsen, E.C., Chen, X. (2006). CDP-choline partly restores phosphatidylcholine levels by affecting PLA2 and CTP-phosphocholine cytidylyltransferase after stroke. American society for neurochemistry, PTW05-7.2.Adibhatla RM, Hatcher JF, Larsen EC, Chen X, Sun D and Dempsey RJ. CDP-choline partly restores the phosphatidylcholine levels by differentially affecting secretory phospholipase A(2) IIA and CTP-phosphocholine cytidylyltransferase after stroke. Poster presented at Experimental Biology, San Francisco, CA, Apr 2006.3.Chen X, Wang Y, Chen H, Kintner DB, Philipson KD, Sun D. Knockdown of Na+/Ca2+ exchanger isoform 1 (NCX1) with SiRNA is neuroprotective in cerebral focal ischemia. (83.19/LL79) Poster presented at 36th annual meeting of Society for Neuroscience, Atlanta,GA, Oct 2006.4.Chen X, Luo J, Kintner DB, Wang Y, Sun D. Na+-K+-Cl- cotransporter contributes to neuronal ER stress and mitochondrial dysfunction following ischemia. (84.8/LL97) Poster presented at 36th annual meeting of Society for Neuroscience, Atlanta,GA, Oct 2006.5.Chen X, and Sun D. Na+-K+-Cl- cotransporter contributes to ER stress in neurons following in vitro ischemia. (55.23/R21) Poster presented at 37th annual meeting of Society for Neuroscience, San Diego, CA, Nov 2007.6.Kintner DB, Chen X, Cramer SW, Luo J, and Sun D. Dysregulation of endoplasmic reticulum calcium in response to oxygen glucose deprivation and reoxygenation: neurons vs. astrocytes. (55.24/R22) Poster presented at 37th annual meeting of Society for Neuroscience, San Diego, CA, Nov 2007.7.Vitzthum L, Chen X, Kintner DB, Huang Y, Williams J, Sun D. The role of Na+/H+ exchangers in the pH regulation of neuronal dendrites: A novel approach with microfluidic devices. (150.4/Y29) Poster presented at 38th annual meeting of Society for Neuroscience, Washington, DC, Nov 2008.8.Kintner DB, Chen X, Matsuda T, Baba A, Cohen M, Taunton J, Sun D. A role for NHE1 and NCX in dysregulation of dendritic ionic homeostasis following in vitro ischemia. (646.18/W31) Poster presented at 38th annual meeting of Society for Neuroscience, Washington, DC, Nov 2008.9.Chen X, and Sun D. Inhibition of Na+-K+-Cl- cotransporter attenuates ERAD dysfunction in neurons following in vitro ischemia. (646.20/W33) Poster presented at 38th annual meeting of Society for Neuroscience, Washington, DC, Nov 2008.10.Sun D, Chen X, Cohen M, Chiu B, Taunton J and Kintner DB. The concerted role of Na+/H+ exchanger and reversal of Na+/Ca2+ exchange in the dysregulation of dendritic Na+ and Ca2+ homeostasis and mitochondrial damage following in vitro ischemia. Poster presented at 39th Annual Meeting of the Society-for-Neuroscience, Chicago, IL, 200911.Liu Y, Kintner DB, Chen X, Algharabli J, Olson J and Sun D. Activation of microglia following in vitro ischemia depends on Na+/H+ exchange-mediated H+ homeostasis. Poster presented at 39th Annual Meeting of the Society-for-Neuroscience, Chicago, IL, 200912.Chen X, Mattson M and Basta M. Inhibition and Scavenging of Complement as Therapeutic Targets in the Mouse Model of Acute Ischemic Stroke (S103) Poster presented at 136th annual meeting of American Neurological Association, San Diego, CA, September 201113.Liu D, Pitta M, Jiang H, Lee JH, Chen X, Zhang G, Mughal M and Mattson M. The NAD+ precursor nicotinamide ameliorates cognitive decline in a mouse model of Alzheimers Disease: evidence for the involvement of CREB, mitochondrial resistance to oxidative stress and autophagy. (665.07/K11) Poster presented at 41th annual meeting of Society for Neuroscience, Washington, DC, Nov 2011.14.Chen X, Lee JH, Wan R., Mughal MR, Liu D, Basta M, and Mattson M. Therapeutic efficacy of natural inhibitors of the complement cascade in a mouse model of focal ischemic. (62.04/FF10) Poster presented at 41th annual meeting of Society for Neuroscience, Washington, DC, Nov 2011.15.Chen X, Mattson M, Basta M. Inhibition and Scavenging of Complement as Therapeutic Targets in the Mouse Model of Acute Ischemic Stroke: S103. Annals of Neurology. 2011 Oct;70. https://onlinelibrary.wiley.com/doi/10.1002/ana.22579Invited Reviews1.Chen, X., Zhao, S., Song, Y., Shi, Y., Leak, R. K., & Cao, G. (2015). The Role of Nicotinamide Phosphoribosyltransferase in Cerebral Ischemia. Curr Top Med Chem, 15(21), 2211-2221. https://doi.org/10.2174/1568026615666150610142234Book Chapters1.Chen, X., and Sun, D. (2008). ER Ca2+ dysregulation and ER stress in cerebral ischemic damage. New Frontiers in Neurological Research. 1-18.2.Eitan, O., Chen, X., Basta, M., Mattson, M. (2011). Roles of Innate Immunity and Inflammation in the Aging Brain. Inflammation, Life Style and Chronic Diseases. 1-36.Other Publications1.Chen, X. (2003). The role of nucleotide excision repair in nephrotoxins-induced DNA damage in human embryonic kidney 293 cells. Masters thesis, Dalian Medical University, Dalian, China2.Chen, X. (2009). Dissertation: ER Ca dysregulation and ER stress in ischemic neurons: role of Na -K -Cl cotransporter. Doctoral dissertation, University of Wisconsin-Madison, Madison, WIPatent2012-presentCombination therapy using immunoglobulin and C1-inhibitor. co-inventor. WO EP US CN JP KR AU CA DK ES HK AUPHONE NUMBER AVAILABLEB2 Xinzhi CHEN Csl Behring Gmbh PCT/EPPHONE NUMBER AVAILABLEOther Scholarly ActivitiesJournal Reviewer2009- 2018Ageing Research ReviewsInternational Journal of NanomedicineInternational Journal of StrokeJournal of Central Nervous System DiseaseJournal of Cerebral Blood Flow & MetabolismJournal of NeurochemistryNeurobiology of AgingNeuroMolecular MedicineTeachingPrimary TeacherTerm/YearsCourse Number &TitleNo. ofStudentsLevelDidactic orClinical2021-2023 SummerNSG 401 - Functional Health Patterns of Adults III- Misericordia University~25/termABSNDidactic/sim2021-2023 SummerNSG 303 - Functional Health Patterns of Adults II- Misericordia University~25/termABSNDidactic/lab/sim2021-2022 FallNSG 201 - Foundations Essential to Professional Nursing Practice- Misericordia University~25/termABSNDidactic/lab1997-2004 Fall,SpringNutrition; Food science; Toxicology; Environmental health; Occupational medicine-Dalian Medical University800/yearJunior/ Senior MSc and ADN/ BSNDidactic/lab/clinicalClinical/Skills Lab Teacher2024 SpringNUR 1020C Advanced Nursing Management of the Adult with Acute/Complex Health Problems7Junior BSNClinical2023 FallNUR 1020C Advanced Nursing Management of the Adult with Acute/Complex Health Problems8Junior BSNClinical2021-2023 SummerNSG 404C Functional Health Patterns Adults IV (Critical care)-Misericordia University8-16/termABSNClinical/Sim2021-2023 SummerNSG 303L - Functional Health Patterns of Adults II Lab- Misericordia University~25/termABSNLab/sim2018 to 2021 Fall, Spring, SummerUPNS 323 Adult Health and Illness -Duquesne University8/semesterJunior /Senior BSN/ABSNLab/clinical/2018 to 2021 Fall, Spring, SummerUPNS 200 Fundamentals of Nursing Practice and Clinical Ethics-Duquesne University8/semesterJunior /Senior BSN/ABSNLab/clinical/2005Teaching Assistant: Zoology 152 -University of Wisconsin-Madison30sophomore BSc.Teaching AssistantGuest LecturerTermCourse Number &TitleNo. of StudentsLevelTopic2022 FallMHH314 Environmental Health~20Junior BSc.Health and Safety in HealthcareSpecialized Contribution1998-2003The original question bank establishment for Chinese national medical licensing examination (MLE) system and training instructor.Mentoring Activities2023Ashley Yang- BSN studentUniversity of Pittsburgh URMP2009Yadira Arellano-Undergraduate studentUniversity of Texas at El Paso2007Adriana Rosale-Undergraduate StudentUW-Madison Integrated Biological Sciences Summer Research Program/ the Ronald McNair Post-Baccalaureate Achievement Program2006Sam Cramer-Undergraduate studentUniversity of Wisconsin-Madison2005Josiah Gerdts- Undergraduate studentUniversity of Wisconsin-Madison2003Huimin Wang- Research fellowDalian medical universityServiceUniversity2023- presentNDFO- University of Pittsburgh-SON2021-2023Misericordia Interprofessional Education Connection (MIPEC)- Misericordia University2021-2023NDFO- Misericordia UniversitySchool of Nursing2023-presentBSN Council - University of Pittsburgh SON2021-2023Undergraduate scholarship committee at the Department of nursing- Misericordia University2021- 2023Facilitator of Open House, the White Coat Ceremony, the Pinning Graduation Ceremony for ABSN nursing students at Misericordia University-Pittsburgh campusCommunity Service/Activities2016-presentProfessional Medical Interpreter (Mandarin), Steel City interpreters, Pittsburgh, PA USAI certify that this curriculum vitae is a current and accurate statement of my professional record.Signature: Date: 04-30-2024