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Click here or scroll down to respond to this candidateCandidate's Name , Ph.D. Curriculum Vitae Page 1Candidate's Name , PH.D.SANFORD RESEARCHStreet Address E. 60th St. N., Sioux Falls, SDPHONE NUMBER AVAILABLEEMAIL AVAILABLEEMAIL AVAILABLEEMAIL AVAILABLEEDUCATIONWELLESLEY COLLEGE, Wellesley, MA 1990 1994B.S. PsychobiologyPURDUE UNIVERSITY, Lafayette, IN 1996 2001Ph.D. Biology, focus on NeuroscienceHARVARD MEDICAL SCHOOL, Boston, MA 2001 2005Postdoctoral Research TrainingMARINE BIOLOGICAL LABORATORY, Woods Hole, MA 2005 2007 Postdoctoral Research TrainingPROFESSIONALSANFORD RESEARCH, CANCER BIOLOGY AND IMMUNOTHERAPIES, Sioux Falls, SD 2015 present Sioux Falls, SDStaff ScientistSOUTH DAKOTA STATE UNIVERSITY, Brookings, SD 2021 present DEPARTMENT OF BIOLOGY & MICROBIOLOGYInstructorUNIVERSITY OF SOUTH DAKOTA SCHOOL OF MEDICINE, Sioux Falls, SD 2017 2022 LecturerNORTHERN STATE UNIVERSITY BIOLOGY DEPARTMENT, Huron, SD 2015 2016 InstructorBRIDGEWATER STATE UNIVERSITY BIOLOGY DEPARTMENT, Bridgewater, MA 2013 2014 Day Associate ProfessorMARINE BIOLOGICAL LABORATORY, Woods Hole, MA 2005 2014 Assistant Research Scientist (20082014)Research Associate (20062007)Postdoctoral Research Scientist (20052006)MASSACHUSETTS GENERAL HOSPITAL, Charlestown, MA 2001 2005 HARVARD MEDICAL SCHOOLResearch FellowMARINE BIOLOGICAL LABORATORY, Woods Hole, MA 1999 2000 Graduate AssistantPURDUE UNIVERSITY DEPARTMENT OF BIOLOGICAL SCIENCES, West Lafayette, IN 1996 2000 Graduate Teaching AssistantTEACHINGSOUTH DAKOTA STATE UNIVERSITY, Brookings, SD 2021 present BIOL 325-325L Physiology and Lab (online)Candidate's Name , Ph.D. Curriculum Vitae Page 2 UNIVERSITY OF SOUTH DAKOTA, SANFORD SCHOOL OF MEDICINE, Vermillion, SD 2017 2022 CPHD 763 Developmental Biology Disease (team taught) Gastrointestinal Diseases, Effects of Alcohol ExpCHEM 725 Genetics of Human Disease (team taught)Neurological & Dominant DiseasesCPD 762 Molecular mechanisms of Disease (team taught) TGF- and BMP Signaling PathwaysNORTHERN STATE UNIVERSITY, Huron, SD 2015 2016BIOL 101L Biology Survey 1Lab;Development of online Introduction to Neurobiology course BRIDGEWATER STATE UNIVERSITY, Bridgewater, MA 2012 2014 General Principles of Biology (Biology 100)Cellular Metabolism, Protein Structure & FunctionNeuronal and Muscular Structure and FunctionBROWN UNIVERSITY, Providence, RI 2012 2013The nuts and bolts of PAK signaling Advanced Biochemistry (Bio1270 PURDUE UNIVERSITY, West Lafayette, IN 1998 2000BIOL 23100 - BIOL III: Cell Structure & FunctionLaboratory BIOL 24100 - Biology IV: Genetics and Molecular Biology MARINE BIOLOGICAL LABORATORY, Woods Hole, MA 1999 2000 Neurobiology and Development of the Leech (19992000) Lecture in What to Expect series for undergraduates (20102011) Mentor in the Biological Discovery in Woods Hole REU program (20112012) Teaching Assistant with Project Micro (20122013)MENTORINGUNDERGRADUATE RESEARCH MENTORINGSANFORD RESEARCH 2017 2022Noah Keime, Andrea Norton, Tanner Diemer, OConnell Qualley, Megan Schaefer, Ariana Azumatan, OConnell BakerMARINE BIOLOGICAL LABORATORY 2010 2014Amy Lilliestrand, Stephanie Spranger, Heather Jackman, Jamie Medina, Patrizia Pellegatti Participant mentor, Biological Discovery in Woods Hole Summer Opportunity for Undergraduate Research, Department of EducationPURDUE UNIVERSITY 1998 2000Orian Furmanski, Brian EinhornTECHNICIANS TRAINED:Shilpa Prabhakar, Vidya Murphy: 20012004Robert Lewis: 20092010GRADUATE STUDENT MENTORINGSANFORD RESEARCH/UNIVERSITY OF SOUTH DAKOTA (USD) 2017 Present DISSERTATION/THESIS COMMITTEESJessica Zylla (Dept. Biomedical Engineering, USD 2019 Present Mariah Hoffman (Dept. Biomedical Engineering, USD 2017 2023 INVITED LECTURESCandidate's Name , Ph.D. Curriculum Vitae Page 3Lessons in Modern Biology: What is Chemobrain? May 2023 Osher Lifetime Learning (OLLI), University of South Dakota, Sioux Falls, SDEpigenetic Modulation in Triple Negative Breast Cancer March 2022 Geographical Management of Cancer Health Disparities Program (GMaP) NCI Career Development Workshop Huntsman Cancer Institute, Salt Lake, UtahWhy have scientists not cured breast cancer yet? March 2021 Osher Lifelong Learning Institute (OLLI), virtualInvestigation of new strategies to modulate the tumor microenvironment April 2021 Department of Pharmaceutical Sciences, South Dakota State University, Brookings, SDMobile Web App Intervention 2021Research Focus Group, Yankton Sioux Advisory Council, Pickstown, SDExploration of Potential Therapeutics for Metastatic Breast Cancer 2019 Science at the Pub; Jims Tap; Brookings, SDTreatments for Neurofibromatosis 2018Graduate Women in Science; Southeast Technical Institute, Sioux Falls, SDExploration of an Epigenetic Approach to Treatment of Solid Tumors 2018 Sanford Research, Sioux Falls, SDDevelopment of Natural Product Therapeutics for Treatments of Tumors 2015 Biochemistry Department, SDSU, Brookings, SDDevelopment of Novel Therapeutics for Treatment of Tumors in NF 2013 Department Biology, Bridgewater State University, Bridgewater, MAInvestigation of MM-121 as a Therapeutic for Tumor Reduction in NF 2012 Merrimack Pharmaceuticals, Cambridge, MAReal Time Monitoring of Extracellular Analytes in the Tumor Microenvironment 2012 NIH Site Visit; Biocurrents Research Center (BRC); MBL, Woods Hole, MDevelopment of New Methodologies to Probe the Intercellular Space 2011 BRC advisory meeting, BRCDevelopment of Therapeutics to Suppress Growth of NF Tumors 2009 Cellular Dynamics Program; MBL, Woods Hole, MAREFEREED JOURNAL ARTICLES( Birth name was Kumar)Sarkar, A., Messerli, S. M., Talukder, M.M.U., & Messerli, M. A. Electric fields polarize initiation and growth of Endothelial Sprouts (2023). Journal of Tissue Engineering and Regenerative Medicine, Vol 2023, Article ID 6331148, https://doi.org/10.1155/2023/6331148.Zhuang, Y., Haugrud, A.B., Schaefer, M. A., Messerli, S. M., & Miskimins, W.K. (2023). The ability of metformin to deplete NAD+ contributes to cancer cell susceptibility to metformin cytotoxicity and is dependent on NAMPT expression. Front. Oncol., 31 July 2023; Sec. Breast Cancer; Volume 132023; https://doi.org/10.3389/fonc.2023.1225220.Soltys, B., Grausam, K. B. Messerli, S. M., Hsia, C. J., & Zhao, H. (2023). Inhibition of metastatic brain cancer in Sonic Hedgehog Medulloblastoma using caged nitric oxide albumin nanoparticles. Frontiers in Oncology; Specialty Section: Pediatric Oncology, Volume 13; https://doi.org/10.3389/fonc.2023.1129533. Hartman, T. W., Radichev, E., Munsub, H. A., Alaba, O., Hoffman, M., Kassa, G., Sani, R., Gadhamshetty, V., Ragi, S., Messerli, S. M., de la Puente, P, Sandhurst, E. Do, T., Lushbough, C, & Gnimpieba, E. Z. (2023). A Semi-automatic workflow, with Machine Learning Segmentation, for Objective Statistical Analysis of Biomedical and Biofilm Image Datasets, Journal of Molecular Biology, Volume 435, Issue 2, 30 January 2023, 167895. Zylla, J. S., Hoffman, M. M., Plesselova, S., Bhattacharya, S., Calcar, K., Afeworki, Y., de la Puente, P., Gnimpieba, E. Z., Miskimins, W. K., & Messerli, S. M. (2022). Reduction of Metastasis via Epigenetic Modulation in a Murine Candidate's Name , S. M. (2020). Analysis of Dual Class I Histone Deacetylase and Lysine Demethylase Inhibitor Domatinostat (4SC-202) on Growth and Cellular and Genomic Landscape of Atypical Teratoid/ Rhabdoid. Cancers, 12, 756; doi:10.3390/cancers12030756. Verma, A. K., Messerli, S. M., & Miskimins, W. K. (2020). Lactate induces PD-L1 in HRASG12V positive oropharyngeal squamous cell carcinoma. Oncotarget, Apr 28;11(17):1493-150. Messerli, S. M., Schaefer, A. M., Zhuang, Y., Keime, N., Jin, J., Ma, L., Soltys, B.H., Hsia, C.J., & Miskimins, W.K(2019). Use of Anti-Metastatic SOD3-Mimetic Albumin as a Primer in Triple Negative Breast Cancer, Journal of Oncology, Article ID 3253696, https://doi.org/10.1155/2019/3253696. Hsia, Messerli, S. M., & Miskimins, K. (2019). An Anti-Metastatic Albumin-based Superoxide Dismutase Mimetic Serve as A Moonshot drug for Treatment for Brain Tumors - From Medulloblastoma to Glioblastoma? Cell Biochem Biophys. Jun; 77(2):121-122. doi: 10.1007/s12013-019-00869-2. Epub 2019 May 15. PMID: 31093886. Messerli, S. M., Hoffman, M. M., Gnimpieba, Kohlhof, H., & Bhardwaj, R. D. (2017). 4SC-202 as a potential treatment for the pediatric tumor medulloblastoma. Brain Sciences, 7, 147; doi: 10.3390/brainsci7110147. Messerli S. M., Hoffman M. M., Gnimpieba, E. Z., & Bhardwaj R. D. (2017). Therapeutic Targeting of PTK7 is Cytotoxic in Atypical Teratoid Rhabdoid Tumors. Mol Cancer Res.Apr 25; PMID: 28442586. Hoffman, M. M.; Minette, C. J., Messerli, S. M., Bhardwaj, R. D., & Gnimpieba, E. Z. (2017). NanoStringBioNetIntegrated R framework for bioscience knowledge discovery from NanoString nCounter data. In Proceedings of the 2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM); IEEE; pp. 21572162.Chowanadisai W., Messerli, S. M., Miller, D. H., Medina, J. E., Hamilton, J. W., Messerli, M. A., & Brodsky, A. S.(2016). Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors. PLoS One. Mar 17; 11(3): e0151089. Doi: 10.1371/journal.pone.0151089. ECollection 2016. PMID: 26986722. Alavian, K. N., Li, H., Collis, L., Bonnanni, L., Zeng, L. Sacchetti, S., Lazrove, E., Nabii, P., Flaherty B., Grahams, M., Chen, Y., Messerli, S. M., Mariggio, M. A., Ratner, C., McNay, E., Shore, G., Smith, P. J., Hardwick, J. M., & Jonas, E. A. (2011). Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase. Nature Cell Biology published online 18 September; DOI: 10.1038/ncb2330. Menachery, A., Graham, D. Messerli, S. M., Pethig, R., & Smith, P. J. S. (2011). Dielectrophoretic tweezer for isolating and manipulating target cells. Institute of Electrical and Electronics Engineer IET Nanobiotechnology, 5 (1): p. 1-7. Prabhakar, S., Brenner, G. J, Sung, B., Messerli, S. M., Mao, J., Sena-Esteves, M., Stemmer Rachamimov, A., Tannous, B., & Breakefield, X. O. (2010). Imaging and therapy of experimental schwannomas using HSV amplicon vector encoding apoptotic protein under Schwann cell promoter. Cancer Gene Therapy, Apr; 17(4): 266-74. Kasinathan, R. S., Goronga, T., Messerli, S. M., Webb, T. R., & Greenberg, R. M. (2010). Modulation of a Schistosoma mansoni multidrug transporter by the antischistosomal drug praziquantel. FASEB J 24, 128-135. Demestre, M., Messerli, S. M., Celli, N., Shahhossini, M., Kluwe, L., Mautner, V., & Maruta, H. (2009). CAPE (Coffee Acid Phenethyl Ester)-based propolis extract (Bio-30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice. Phytotherapy Research, Feb; 23(2): 226-30. Messerli, S. M., Ahn, M-R., Kunimasa, K., Yanagihara, M., Tatefuji, T., Hashimoto, K., Mautner, V., Uto, Y., Hori, H., Kumazawa, S., Kaji, K., Ohta, T., & Maruta, H. (2009). Artepillin C (ARC) in Brazilian Green Propolis selectively blocks the oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice. Phytotherapy Research, Mar; 23(3): 423-7.Messerli, S. M., Kasinathan, R. S., Morgan, W., Spranger, S., & Greenberg, R. M. (2009). Schistosoma mansoni P- glycoprotein levels increase in response to praziquantel exposure and correlate with reduced praziquantel susceptibility. Mol Biochem Parasitol, Sept 167(1): 5459. Prabhakar, S., Messerli, S. M., Stemmer-Rachmimov, A., Liu, T., Samuel Rabkin, S., Martuza, R., & Breakefield, X. O.(2007). Treatment of implantable NF2 schwannoma tumor models with oncolytic herpes simplex virus G47D. Cancer Gene Therapy, 1-8.Candidate's Name , S. M., Prabhakar, S., Tang, Y., Shah, K., Cortes, M. L., Murthy, V., Weissleder, R., Breakefield, X. O., & Tung, C. (2004). A novel method for apoptosis imaging is an ICE (caspase-1) near-infrared fluorescent imaging probe. Neoplasia, 6(2): 1-11.Stemmer-Rachamimov, A., Louis, D. N., Nielsen, G. P., Antonescu, C., Borowsky, A., Bronson, R., Burns, D. K., Cervera, P., McLaughlin, M., Reifenberger, G., Schmale, M., MacCollin, M., Chao, R., Cichowski, K., Kalamarides, M., Messerli, S. M., McClatchey, A., Niwa-Kawakita, M., Ratner, N., Reilly, K., Zhu, Y. & Giovannini, M. (2004). Comparative pathology of nerve sheath tumors in mouse models and humans. Cancer Research, 64 (10), 3718-3724. Tang, Y., Shah, K., Messerli, S. M., Snyder, E., Breakefield, X. O., & Weissleder, R. (2003). In vivo tracking of neural progenitor cell migration to glioblastomas. Human Gene Therapy, 14 (13):1247-54. Messerli, S. M., Tang, Y., Giovannini, M., Bronson, R. T., Weissleder. R. & Breakefield, X. O. (2002). Detection of spontaneous schwannomas by MRI in a transgenic murine model of neurofibromatosis type2. Neoplasia, 4(6): 501- 509.Kumar, S. M., Porterfield, D. M., Muller, K. J., Smith, P. E., & Sahley, C. L. (2001). Nerve Injury induces a rapid efflux of nitric oxide (NO) detected with a novel NO microsensor. The Journal of Neuroscience, 21(1):215- 220. Chen A.* Kumar, S. M.*, Sahley, C. L., & Muller, K. J. (2000). Nitric oxide influences injury-induced microglial migration and accumulation in the leech CNS, The Journal of Neuroscience, 20(3): 1036-1043. Shafer, O. T., Chen, A., Kumar, S. M., Muller, K. J., & Sahley, C. L. (1998). Injury-induced expression of endothelial nitric oxide synthase by glial and microglial cells in the leech central nervous system within minutes after injury. Proc. R. Soc. Lond. B, 265 (1411): 2171-2175.Lipton, S. A., Kim, W. K., Choi, Y. B., Kumar, S., DEmilia, D. M., Rayudu, M. V., Arnelle, D. R., & Stamler, J. S.(1997). Neurotoxicity is associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc. Natl. Acad. Sci. USA, 94(11): 5923-8.BOOKS/MONOGRAPHS (AUTHORED AND/OR EDITED VOLUMES)Maruta, H., Messerli, S. M., & Ramesh, J. (2013). Natural or synthetic therapeutics that block PAKs in PAKs, RAC/CDC42 (p21)-activated Kinases. Towards the Cure of Cancer and Other PAK-dependent Diseases, ISBN: 978- 0-12-407198-8, pp.53-76.Maruta, H., & Messerli, S. M. (2013). PAK1 in brain diseases or disorders in PAKs, RAC/CDC42 (p21)- activated kinases. Towards the Cure of Cancer and Other PAK-dependent Diseases, PHONE NUMBER AVAILABLE, Elsevier, Oxford, UK, pp. 87-106, 10.1016/BPHONE NUMBER AVAILABLE.00005-9. CHAPTERS IN BOOKSMaruta, H. & Messerli, S. M. (2010). Development of new anti-cancer drugs that block the kinase PAK1. Frontiers in Drug Design and Discovery, Bentham Books, pp.121-46. PATENTSMesserli, M. A., Heart, E., Xu, M., and Messerli, S. M. (2017). Methods and systems of detecting exocytosis of a target population of cells, US Patent Application No 61/88, 639. ACADEMIC HONORS TO THE PROFESSIONCandidate's Name , Ph.D. Curriculum Vitae Page 6 Geographical Management of Cancer Health Disparities (GMAP) 2017 2023 Research Scholar Travel AwardsSDSU Quality Assurance Review, Score: Highest Commendable 2021 2022 NF Cure Japan Award 2007 2009MGH Fund for Medical Discovery Award 2002 2003U.S. Department of Education, GAAN Fellowship 1997 2000 Zimmerman Grant, Wellesley College, Wellesley, MA 1994 1995 SERVICE ON NATIONAL AND INTERNATIONAL COMMITTEESAcademic Editor on Editorial Board of IET Nanobiotechnology 2023 2026 The Institution of Engineering and Technology (IET) International Examiner for Ph.D. thesis defense of Dr. Liu He, University of Melbourne, 2012 2013 Austin Health, Heidelberg Victoria, Australia Study Sections Neurofibromatosis Research Program - NF- Basic Science 2012 2014 Department of Defense, United States Army Medical Research and Material Directed Medical Research ProgramsSERVICE TO THE COMMUNITY / SCIENCE OUTREACHGroup leader, Science Booth, Junior Achievement, Aspire of South Dakota, Sioux Falls, SD 2023 Breast Cancer Screening Educational Seminar, 2020- 2021 Yankton Sioux Tribe Advisory Council, Pickstown, SD Data Club Committee, Sanford Research, Sioux Falls, SD 2020 2021 Keloland RadioFeatured in: Sanford Health Scientist to Study Potential Breast Cancer 2020 Treatment, Its Use for American Indian Women;Midwest Medical Edition & Capital JournalLecturer, Science at the Pub, Jims Tap, Brookings, SD 2019 Presenter, 13th Annual Women in Science, Sioux Falls, SD 2018 Discovery Day Group Leader, Sanford Research, Sioux Falls, SD 2019-2020 Safety Committee, Sanford Health, Sioux Falls, SD 2018-2020 Group Leader, Women in Science, Sioux Falls, SDGroup Teacher /Leader for the Dairy Fest, Swiftel Center, Brookings, SD Volunteer, Special Olympics, Brookings, SD 2015Volunteer, Brookings Humane Society, Brookings, SD 2014- 2015 Judge for Regional Science Fair, South Dakota University, Brookings, SD 2018 Group Leader, Women in Science, Southeast Technical Institute, Sioux Falls, SD 2017 Woods Hole Science and Technology Education (WHSTEP) Mentor 2013-2014 Marine Biological Laboratory, Woods Hole, MAScience Fair Judge, Massachusetts State Science Fair 2013 Massachusetts Institute of Technology (MIT), Cambridge, MA Direct Firsthand Science Exhibit Nature Holds the Cure Discovery Day 2013 Marine Biological Laboratory, Woods Hole, MAMentor to Students for Falmouth High School Science, Falmouth, MA 2011 ADDITIONAL TRAINING AND CERTIFICATIONMassachusetts institute of Technology, Institute for Data, Systems, & Society (IDSS) 2023 present Data Science & Machine Learning: Making Data-Driven Decisions program; virtual Experience with Digital Teaching Resources 2013 present Expertise in open-source Learning Management Systems (Desire2Learn and Moodle) Proficiency in digital teaching and learning systems (Connect & LearnSmart) BioSNTR Bioinformatics Training Workshop, Sioux Falls, SD 2017 BioSNTR Faculty Member 2016 presentCandidate's Name , Ph.D. Curriculum Vitae Page 7 Collaborative Institutional Training Initiative (CITI) Training 2017 2022 Costarters Boot Camp, Startup Sioux Falls 2023Massachusetts Institute of Technology Institute for Data Systems & Society (IDSS) 2023 2024 Data Science and Machine Learning: Making Data-Driven Decisions program AD HOC REVIEWER 2007 presentCancersHuman Gene TherapyMolecular Cancer ResearchBrain SciencesJournal of Bioinformatics Journal of Clinical Medicine Institute of Engineering and Technology (IET) Nanobiotechnology PROFESSIONAL MEMBERSHIPSSociety for Neuroscience 1997 2001Graduate Women in Science 2016 presentAmerican Association for Cancer Research (AACR) 2013 present BIOSNTR faculty member 2017 presentSouth Dakota Biotech 2022 presentSouth Dakota Academy of Sciences 2022 presentAWARDSGMAP Research Scholar Travel Awards 2017 2023Image of the Day: My schwannoma in the Scientist 2013 MGH Fund for Medical Discovery 2003 2004Zimmermann Grant (undergraduate) 1993SELECTED RECENT CONFERENCE ABSTRACTS( Birth name was Kumar)Messerli, S. M., Kumar, R., Raina, K., Hsia, C.J.C., Simoni, J., & Miskimins, K. (2023). Investigation of the use of macromolecular superoxide dismutase mimetics to reduce adverse effects induced by chemotherapy in a murine model of triple negative breast cancer. Cancer COBRE conference, Sioux Falls, SD Messerli, S. M., Rabl, R., Prokesch, M., Soltys, B., Simoni, J., & Miskimins, K.W. (2023). Neuroprotection and cognitive improvement using VACNO and SanFlow in the scopolamine model for Alzheimers Disease. DaCCOTA Annual Symposium, virtual.Messerli, S. M., Rabl, R. Prokesch, M., Soltys, B., Simoni, J., Hsia, C, & Miskimins, K. (2023). Neuroprotection and cognitive improvement using VACNO and SanFlow in the scopolamine model for Alzheimers Disease. 7th Annual Eastern South Dakota Research Symposium.Messerli, S. M., Schaefer, A., Hsia, C., Simoni, J., & Miskimins, K. (2022). Protection against chemotherapy adverse events by macromolecular Superoxide Dismutase Mimetics in breast cancer. 6th Annual Eastern South Dakota Research Symposium, Sioux Falls SD.Azumatan, A., Zylla, J. Hoffman, M., Tecleab, Y., Gnimpieba, E., Miskimins, K., & Messerli, S. M. (2021). Effect of 4SC-202 and Glutaminase Inhibitor on Triple Negative Breast Cancer (TNBC). Sanford Research Summer Symposium, Sanford Research, Sioux Falls, SD.Messerli, S. M., Schaefer, M., Haugrud, A., Zhuang, Y., & Miskimins, K. W. (2021). The ability of metformin to deplete NAD+ contributes to cancer cell susceptibility to metformin cytotoxicity and is dependent on NAMPT expression. Eastern South Dakota Symposium, Sioux Falls, SD.Messerli, S. M, Hoffman, M. M., Zylla, J. S., Gnimpieba, E., & Miskimins, K. W. (2021). Evaluation of therapeutic potential of epigenetic modulation using the dual HDAC/LSD1 inhibitor 4SC-202 in murine models of Triple Candidate's Name , S. M., Hoffman, M. M., Zylla, J. S., Gnimpieba, E., & Miskimins, K. W. (2020). Evaluation of therapeutic potential of epigenetic modulation using the dual HDAC/LSD1 inhibitor 4SC-202 in murine models of Triple Negative Breast Cancer (TNBC) [poster]. In Proceedings of the University of South Dakota Chapter of Society for Biomaterials Day; Sioux Falls, SD.Hoffman, M., Minette, C., Messerli, S. M., Bhardwaj, R., & Gnimpieba, E. (2017). NanoStringBioNet: Integrated R Framework for Bioscience Knowledge Discovery from NanoString nCounter Data: p2037536: S24203: International Conference on Bioinformatics and Biomedicine (BIBM), Kansas City, MO. Messerli, S. M., Schaefer, A. M. Lin, J. Ma, L., Soltys, B. Hsia, C., & Miskimins, K. (2017). Polynitroxylated Albumin: A Novel Macromolecular Anti-Metastasis Drug for Triple Negative Breast Cancer; Triple Negative Breast Cancer International Conference, Illuminating Actionable Biology, Georgia State University, Atlanta, Georgia. Messerli, S. M., Killian, M., Bartz, Rene, Kohlhof, H., Bhardwaj, R. D. (2017). Small molecule 4SC- 202 as a potential treatment for pediatric brain tumors. First Annual GMap Region 6 Meeting, Salt Lake City, Utah. Messerli, S. M., Hoffman, M., Gnimpieba, E., & Bhardwaj, R. (2016). Investigation of Pharmacological therapies for Atypical Teratoid Rhabdoid tumor (ATRT). Pediatric Symposium, Sanford Research, Sioux Falls, SD. Messerli, S. M., Birkeland, S. R., Morgan, W., Bernier, J., Cipriano, M. J., McArthur, A. G., & Greenberg, R. M. (2006). NO-induced upregulation of extracellular superoxide dismutase in Schistosoma mansoni, Soc. Neurosci. Abs, Atlanta, Georgia.Messerli, S. M. & Bhardwaj, R. (2016). Precision based Medicine targets Atypical Teratoid rhabdoid tumors (ATRT). 7th Annual USD-Sanford Health Biomedical Research Symposium, University of South Dakota Sanford School of Medicine, Vermillion, SD.Messerli, S. M., Demestre, M., Ahn, M. R. Yanagihara, M., Tatefuji, T., Uto, Y., Hori, H., Mautner, V., Hashimoto, K., Kumazawa, S., Ohta, T., & Maruta, H. (2014). Natural product therapeutics suppresses the growth of human Neurofibromatosis (NF) tumors and gliomas. Marine Biological Laboratory- University of Chicago retreat, Woods Hole, MA.Messerli, S. M., Demestre, M., Ahn, M. R. Yanagihara, M., Tatefuji, T., Uto, Y., Hori, H., Mautner, V., Hashimoto, K., Kumazawa, S., Ohta, T., & Maruta, H. (2009). Anti-PAK1 products Bio 30 and Brazilian Green Propolis Extract(GPE) suppress the growth of human NF and glioma xenografts in mice. American Association of Cancer Research(AACR) 100th.Messerli, S. M., Prabhakar, S., Tang, Y., Weissleder, R., & Breakefield, X. O. (2003). Treatment of schwannomas in transgenic murine model of Neurofibromatosis Type 2 (NF2) using both HSV recombinant and amplicon vectors. Molecular Therapy, 7(5), Part 2 of 2, S91.Messerli, S. M., Tang, Y., Giovannini, M., Prabhakar, S., Murthy, V., Todo, T., Rabkin, S., Martuza, R., Bronson, R., Stemmer-Rachmaninov, A., Weissleder, R., & Breakefield, X. O. (2003). Treatment of schwannomas with an oncolytic HSV replication conditional vector in a NF2 transgenic model. XXVII MGH Research Symposium and poster session (SAC), 70.Kumar, S. M., Tang, Y., Giovannini, M., Bronson, R. T., Weissleder, R., & Breakefield, X.O. (2002). Detection of spontaneous schwannomas by MRI in a transgenic murine model of Neurofibromatosis Type 2 (NF2). Molecular Therapy. 5(5), Part 2 of 2, S99.Kumar, S. M., Tang, Y., Shah, K., Giovannini, M., Weissleder, R., & Breakefield, X. O. (2002). Gene delivery to schwannomas in a transgenic murine model of Neurofibromatosis Type Molecular Imaging, 1 (3), 284. Kumar, S. M., Tang, Y., Giovannini, M., Bronson, R., Weissleder, R., & Breakefield, X. O. (2002). Detection of spontaneous schwannomas by MRI in a transgenic murine model of Neurofibromatosis type 2, American Society for Gene Therapy abstract, 5th annual meeting for American Society of Gene Therapy, 299. Kumar, S. M., Muller, K. J., Carrasco, R. A., Furmanski, O., & Sahley, C. L. (2000). Nitric oxide induced at nerve lesions stops migrating microglia by activating soluble guanylate cyclase in the leech CNS. Soc. Neurosci. Abs. 26(2), 506.11.Kumar, S. M., Porterfield, D. M., Muller, K. J., Sahley, C. L. & Smith, P. J. S. (1999). In situ measurement of injury- Candidate's Name , Ph.D. Curriculum Vitae Page 9 induced nitric oxide (NO). Soc. Neurosci. Abs. 25 (1). Kumar, S. M., Furmanski, O., Sahley, C. L. (1998). Injury-induced NOS activity and microglial accumulation in the leech CNS depend on calmodulin. Soc. Neurosci. Abs. 24(1) 67, 32.18. Kim, W. K., Rayudu, P. V., Choi, Y. B., Kumar, S., Stamler, J. S., & Lipton, S. A. (1995). Homocysteine: An NMDA agonist and glycine site partial antagonist that induces cortical neurotoxicity. Soc. Neurosci. Abs. 21 (1), 521. RESEARCH SUPPORTW81XWH-20-BCRP-BTA12 (Miskimins)U.S. Army Medical Research and Development Command; Department of Defense Title: Protection against chemotherapy adverse events by macromolecular superoxide dismutase mimetics in breast cancerPeriod: 01/01/202112/31/2025Role: Co-InvestigatorCOMPLETED RESEARCH SUPPORTP20GM103548-09 (Miskimins) NIH/NIGMSTitle: Investigation of the mechanism by which metformin induces cytotoxicity in Triple Negative Breast Cancer (TNBC).Period: 04/01/202006/01/2022Role: Pilot Project LeadGeographical Management of Cancer Health Disparities (GMaP) National Institutes of Health (NIH)/National Cancer Institute (NCI) Title: Epigenetic regulation by dual Histone Deacetylase (HDAC1) and Lysine Demethylase (LSD1) inhibition in Triple Negative Breast Cancer (TNBC) and its potential application to the American Indian (AI) population.Period: 07/01/202007/01/2022Role: Pilot Project Lead2P20GM103548-08 (Miskimins) NIH/NIGMSProgram: Center for Cancer Biology ResearchTitle: Further evaluation of HDAC inhibitor 4SC-202 in murine models of metastatic breast cancer. Period: 01/01/201902/29/2020Role: Pilot Project Lead2P20GM103548-10S1 (Miskimins) NIH/NIGMSTitle: Effect of Novel Extracellular Superoxide Dismutase Mimetics in the Scopolamine Cognitive Impairment Model for Alzheimers Disease. Period: 07/01/202006/30/2022Role: Staff Scientist2P20GM103548-07 (Miskimins) NIH/NIGMSProgram Title: Center for Cancer Biology ResearchTitle: Therapeutic potential of HDAC inhibitor 4SC-202 in murine models of metastatic breast cancer. Period: 01/01/2018 12/31/2018Role: Pilot Project LeadR01 CA180033-04 (Miskimins) National Cancer Institute (NCI) Title: (PQA1) Molecular mechanisms by which the diabetic drug metformin kills cancer cells. Period: 02/08/2013 12/31/2018Role: Staff ScientistB1355423 BioSystems Networks and Translational Research (BioSNTR) Title: Predictive model and single cell transcriptomic profiling in Atypical Teratoid Rhabdoid Tumors (ATRT).Candidate's Name , Ph.D. Curriculum Vitae Page 10 Period: 11/16/201606/30/2017Role: Co-InvestigatorP41 RR001395-27, National Center for Research Resources (Smith) Title: Electrochemical detection using functionalized nanoparticles. Period: 12/01/200811/30/2009Role: Co-InvestigatorP41 RR001395-27, National Center for Research Resources (Smith) Title: Neurofibromatosis.Period: 12/01/200811/30/2009Role: Pilot Project LeadMerrimack PharmaceuticalsTitle: Investigation of the effect of MM-121 on growth of Neurofibromatosis (NF) tumors. Period: 01/01/201201/01/2014Role: Principal InvestigatorPeterson FoundationTitle: Development of effective Neurofibromatosis (NF) therapeutics. Period: 01/ 01/200901/2011Role: Principal InvestigatorYamada Bee FarmTitle: Investigation of effect of Artepillin C on growth of Neurofibromatosis (NF) tumors Period: 01/01/201101/01/2012Role: Principal InvestigatorMassachusetts General Hospital MGH Fund for Medical Discovery Title: Investigation of HSV gene therapy for |
