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Click here or scroll down to respond to this candidateCandidate's Name , M.D., Ph.D.Scientific Director - ProfilePrincipal ScientistLead ScientistPhiladelphia, PA PHONE NUMBER AVAILABLEEMAIL AVAILABLEhttps://LINKEDIN LINK AVAILABLEQualifications SummaryDoctor of Medicine and Pharmaceutical Science with extensive research experience in the university environment. Broad expertise across animal models of cardiovascular diseases, endovascular interventions, restenosis, atherosclerosis, gene therapy, cell therapy, ad/AAV vectors, nitric oxide and reactive oxygen species physiology and pharmacology, drug and gene delivery systems, biomaterials, bioconjugation chemistry, optical imaging, histology, immunohistochemistry and immunofluorescence techniques, fluorescence microscopy, pathology, cell culture techniques, and assay development. Guides the design and implementation of biomedical experiments to contribute innovative advancements in the field.Core CompetenciesCardiovascular DiseaseGene/Cell TherapyDrug/Gene Delivery SystemsAnimal ModelsImmunohistochemistryAssay Development/ELISAControlled ReleaseEndovascular InterventionsAd Vectors/AAV VectorsBiomaterials/BiopharmaceuticsOptical ImagingFluorescence MicroscopyBiomedical ExperimentsMagnetic TargetingRestenosis/AtherosclerosisPhysiology/PharmacologyBioconjugation ChemistryHistology/PathologyMacrophage BiologyCell Culture TechniquesProject Design/ManagementEducationDoctor of Medicine School of Medicine, University of Saratov, Saratov, USSRDoctor of Philosophy in Pharmaceutical Science Hebrew University of Jerusalem, Jerusalem, IsraelCertificationEducational Commission for Foreign Medical Graduates (ECFMG) Certificate, USAGeneral Medical Practice, IsraelLicensureLicensing Council, Israeli Ministry of Health, activeCareer ExperienceSchool of Medicine University of Pennsylvania, Philadelphia, PA 2015 PresentResearch Associate Professor of PediatricsConducted research on:Chemical modification and fluorescent labeling of Ad, AAV, and lentiviral vectors;Developing a magnetic delivery/targeting catheter and characterizing it in the porcine femoral model;Macrophage biology in vasculo-proliferative diseases;Elucidating the role of macrophage polarization in in-stent restenosis;Developing AAV-eluting stents;Comparing the long-term effects of permanent metal stents and biodegradable polymeric stents on arterial remodeling and restenosis;Improved histological processing of stented arteries (tissue-sparing chemical stent dissolution);Developing a software for automatic analysis of microscopic images;Surface modification of Ad and AAV vectors with proteolytic enzymes for enhanced vector spread through solid tumors;AAV-based gene delivery of an oxidation-resistant apoA1 variant (apoA1-4WF) for the prevention of restenosis in the porcine coronary model;The anti-atherosclerotic and anti-restenotic effects of blood outgrowth endothelial cells transduced with wild-type apoA1 and apoA1-4WF;Accelerated reendothelialization of endovascular stents using the enhanced attachment of biotinylated endothelial cells to avidin-functionalized stents;Stent functionalization with CD47 and CD47-derived peptides for the prevention of in-stent restenosis in the rabbit iliac model.Authored and published 25 research studies, six reviews/book chapters, and 31 conference abstracts.Mentored four postdoctoral fellows, a graduate cell and molecular biology student, one graduate pharmacology student, and five undergraduate bioengineering students.Served as an external examiner for a doctoral thesis.Served as a reviewer of 73 papers.Presented research at five invited presentations.Research Assistant Professor of Pediatrics, School of Medicine 2005 2015Conducted research on:Chemical modification of Ad vectors;Methods of Ad vector purification;Reversible immobilization of non-viral gene vectors and Ad vectors to the surfaces of bioimplants;Use of protein transduction domains for transduction enhancement with Ad vectors;Use of multifunctional polymers for photoactivatable conjugation to the surface of PLA/PLGA nanoparticles and gene vectors;Developing anti-knob antibody-based and CAR-D1-based adaptors for targeted delivery of Ad vectors;Magnetic field-facilitated delivery of Ad/magnetic nanoparticle complexes in vitro and in vivo;Developing gene-eluting stents;Bioluminescence-based detection of reactive oxygen species in the stent-injured vessel wall;Developing a new rat model of carotid artery stenting and adapting it for use in gene-eluting stent studies.Authored and published 16 research papers, four reviews/book chapters, and 18 conference abstracts.Courses taught include Principles of Cardiovascular Biology and a seminar on Cardiovascular Gene Therapy.Mentored four postdoctoral fellows, two graduate pharmacology students, one medical student, and one undergraduate bioengineering student.Presented research at seven invited presentations.Served as a reviewer for 52 papers.Previous ExperiencePostdoctoral Fellow Division of Cardiology, Children's Hospital of PhiladelphiaReservist Service Member, Medical Corps Israel Defense Army, IsraelStaff Physician, Department of Cardiology Hospital #26, Kiev, UkraineStaff Physician, Department of Cardiology Central Hospital #6, Penza, RussiaIntern in Medicine Central Hospital #6, Penza, RussiaHonors & AwardsInnovation Award, Stokes Fellows Research Poster Day, Children's Hospital of PhiladelphiaGoldhaber Family Award for Academic Achievements, Hebrew University of JerusalemThe Nagai Foundation Graduate Student Award, Controlled Release SocietyGrantsPendingRole: Primary Investigator, Stent surface modification with programmable hydrolysable polymers for prevention of restenosis, NIH/NIBIB, July 2023 June 2027, $499,412, 40% effortRole: Primary Investigator, Stent surface modification with programmable hydrolysable polymers for prevention of restenosis, AHA, Collaborative Sciences Award, July 2023 June 2026, $250,000, 30% effortRole: Primary Investigator, AAV-IL10 platelet membrane cloaking for enhanced vascular wall transduction and restenosis mitigation, AHA, Innovative Project Award, July 2023 June 2025, $100,000, 25% effortRole: Primary Investigator, Enhanced in situ stent endothelialization via biotin/avidin affinity coupling, NIH/NHLBI R01, April 2023 March 2027, $361,314, 50% effortCurrentRole: Co- Primary Investigator, Oxidation Resistant ApoA1 Gene Delivery Stents, NIH/NHLBI, 1R01HL137762, July 2017 June 2023, $627,879, 40% effortPast17 grants full details available upon requestPatentsU.S. Patent # 9,694,103, Photo-chemical activation of surfaces for attaching biomaterial. Alferiev, Fishbein, Chorny, Levy, 2017.U.S. Patent # 9,095,610 B2, Uniform Field Magnetization and Targeting of Therapeutic Formulations. Levy R, Polyak B, Chorny M, Fishbein I, Alferiev I, Friedman G, Williams D., 2015.U.S. Patent # 9,084,877, Magnetic targeting device, system and method. Levy, Chorny, Fishbein, 2015.U.S. Patent # 9,084,877 B2, Magnetic targeting device, system and method. Levy, Chorny, Fishbein. 2015.U.S. Patent # 8,562,505 B2, The Children's Hospital of Philadelphia: Uniform field magnetization and targeting of therapeutic formulations. Alferiev IS, Chorny M, Fishbein I, Friedman G, Levy RJ, Polyak B, Williams D., 2013.U.S. Patent # 8,580,545, The Children's Hospital of Philadelphia: Biodegradable linkers for molecular therapies. Alferiev IS, Fishbein I, Levy RJ, 2013.U.S. Patent # provisional application RCHP-195USP, The Children's Hospital of Philadelphia: Ex vivo-modified monocytes as local delivery vehicles to treat diseased arteries. Fishbein I, Levy RJ, 2011.U.S. Patent # 7,846,201, The Children's Hospital of Philadelphia: Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex. Chorny M, Polyak B, Fishbein I, Alferiev IS, Levy RJ, 2010.U.S. Patent # 7,589,070, The Children's Hospital of Philadelphia: Surface modification for improving biocompatibility. Levy RJ, Alferiev IS, Song C, Fishbein I, 2009.U.S. Patent # 7,635,734, The Children's Hospital of Philadelphia: Photochemical activation of surfaces for attaching biomaterial. Alferiev IS, Fishbein I, Chorny M, Levy RJ, Yellen BB, Williams D, 2009.U.S. Patent # 6,890,998, The Children's Hospital of Philadelphia: Thiol activation of polyurethanes and methods of making the same. Alferiev IS, Fishbein I, Levy RJ, 2005.U.S. Patent # 6,900,282, The Children's Hospital of Philadelphia: Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same. Alferiev IS, Fishbein I, Levy RJ, 2005.Patent # EP10948220B1, The Hebrew University of Jerusalem: Use of bisphosphonates in the treatment of vascular restenosis. Golomb G, Danenberg HD, Monkkonen J, Fishbein I, 2004.U.S. Patent # USPHONE NUMBER AVAILABLEA1*, The Children's Hospital of Philadelphia: Methods of determining surface binding capacity. Alferiev IS, Fishbein I, Levy RJ, 2004.U.S. Patent # WO02103004A1*, The Children's Hospital of Philadelphia: Surface modification for improving biocompatibility. Alferiev IS, Fishbein I, Levy RJ, 2002.CommitteesVoting Member, Executive Board, Clinical and Scientific Advisory Committee (CSAC), Pennsylvania Pediatric Device Consortium (PPDC), 2018 PresentMember, CSAC, PPDC, 2013 PresentOrganizing Committee Member, 3rd International Conference on Translational Medicine, Las Vegas, NV, 2014Voting Member, Scholarship Oversight Committee, Division of Cardiology, Children's Hospital of Philadelphia, 2010 PresentEditorial Board PositionsEditorial Board Member, Angiology, 2013 PresentEditorial Board Member, Journal of Functional Biomaterials, 2021 PresentAssociate Editor, Frontiers in Cardiovascular Research, 2023 Present(Reviewer of numerous scientific journals, full details available upon request)Publications & Presentations48 peer-reviewed research publications1 non-peer reviewed research publication10 peer-reviewed reviews of research publications59 abstracts7 chapters, editorials, reviews, and committee reports12 invited lecturesFull details available upon requestAffiliationsMember, American Society of Gene and Cell TherapyMember, American Heart AssociationLanguagesEnglish, Hebrew, Russian, UkrainianTechnical ProficienciesLaboratory Techniques: Cell culture, transfection, transduction, RT-PCR, Western blot, ELISA, spectrophotometry, fluorimetry, luminometry, chromatography, biochemical assaysSoftware: Microsoft Office, EndNote, GraphPad, Imaging and image analysis software (NIH Image, Image J, Living Image, Photoshop), SnapGene, SoftMax Pro |
