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Click here or scroll down to respond to this candidatePROFILEMolecular Biologist, Biochemist Computational Chemist Molecular Modeler AMBER Software Clinical Trial Analysis Statistical Analysis Scientific instruction, writing and consulting Published first author in top-tier biomedical journals Strong editing/proofreading skills Bioinformatician, Cell Biologist Cellular and Molecular Biology Cloning Recombinant Proteins High-Resolution Binding Assays High Throughput Screening Tissue and Cell Culture PCR, Western Blotting ELISA Drug Discovery Using In Silico Molecular Simulations Bioinformatics including Homology Modeling Presenter at conferences, seminars, poster sessions Strong editing/proofreading skills Proficient in Zoom, Webex, and Microsoft Office SuitePROFESSIONAL EXPERIENCENew Jersey Department of Community Affairs, Somerville, NJ June 2019 - PresentCase Manager, AuditorNew Jersey Educational Services Commission, Somerville, NJ July 2018 June 2019Instructor in Adult Education in ScienceAxa Solutions, Incorporated, New York, NY (Remote) June 2003 PresentResearch Analyst / ScientistConsulting/Reporting on Educational Software Used in K-12 Science and Mathematics EducationGeorgia State University August 2001 May 2003Atlanta, GeorgiaResearch AssociateDevelopment of Novel Antibiotics Using DNA-Drug Simulations: molecular modeling of complexes of planar aromatic antibiotics with major and minor grooves of DNA oligonucleotides using energy minimization and molecular dynamicsRan 10 nanosecond molecular dynamics simulations with detailed analysis of RMS variation from starting atom positions, bond length, angle and torsion variations to show stability of bound complexThe University of Georgia June 1999 July 2001Athens, GeorgiaResearch AssociateDNA-Protein Simulations: molecular dynamics simulations of transcription factors bound to oligonucleotides; gained detailed insight into conformational variability from crystal structureStructure-Function Studies on Glycoproteins including those involved in rheumatoid arthritis using energy minimization and molecular dynamicsEmory University June 1998 May 1999 and Oct 1992 Mar 1995Atlanta, GeorgiaResearch AssociateAb initio calculations of enzyme active site conformations including electronic charge distribution using quantum mechanics/molecular mechanics (QM/MM)Used molecular dynamics on DNA oligonucleotides containing dihydrouridine-cytidine pairs, discovered new possible DNA backbone conformations caused by distortion of thymine to dihydrouracil and the resulting carcinogenic and mutagenic effectsPacific Northwest National Laboratories April 1995 May 1998Richland, WashingtonPostdoctoral FellowDNA Repair Studies: Molecular modeling of DNA oligonucleotides containing chemically modified bases; interfaced with bioinformaticians and performed bioinformatics computations to analyze genomics data for the purpose of understanding pathways of resistance and differentiation to anticancer drugsPerformed sophisticated energy minimization and molecular dynamics simulations of up to 10 nanoseconds to show energetic of structural modification of backbone and basesStanford University June 1991 Sept 1992 Stanford, CaliforniaPostdoctoral FellowInvestigation of effects on liver enzyme CYPIA1 gene transcription caused by carcinogens such as dioxin; techniques included in vitro transcription assays, preparation of nuclear extracts from mouse hepatoma cells, chromatography and gel electrophoresis; evaluated mechanisms of drug resistanceUniversity of California Dec 1989 May 1991 San Diego, CaliforniaPostdoctoral FellowDevelopment of Novel Cyclic Opioid Analogs: Determined optimal configuration for binding of opioid analogs to mu and kappa receptors in the rat brain based on NMR structures by means of energy minimization and molecular dynamics of cyclic opioid peptides in conjunction with in vitro opioid assaysEDUCATION, TEACHING & VOLUNTEER SERVICEPh.D. Degree / Masters Degree - Princeton University Princeton, New JerseyMolecular BiologyDoctoral Thesis Research Princeton University Princeton, New JerseyTriplex formation of double stranded DNA with RNA oligomers, characterized binding affinityand base sequence requirementsUsed DNAse and diethyl pyrocarbonate footprinting, gel retardation and transcriptionassays to determine structural / functional effects of third strand bindingAssistant in Instruction Princeton UniversityInstructed and managed groups of 10 to 12 undergraduate students in core biochemistry laboratoryand lecture courses, including office hours and grading of lab reports and problem setsBachelor of Arts Degree - Columbia University New York, New YorkChemistryHigh School Diploma - The Dalton School New York, New YorkValedictorianPUBLICATIONSCooney, Michael G. & Miller, J.H. (1997). Calculated Distortions of Duplex DNA by a Cis, Syn Cyclobutane Thymine Dimer Are Unaffected by a 3 TpA Step. Nucleic Acids Research (25) 7, pp.1432-1436. PMID: 9060440 (https://www.ncbi.nlm.nih.gov/pubmed/9060440)Miaskiewicz, K., Miller, J., Cooney, Michael & Osman, R. (1996). Computational Simulations of DNA Distortions by a cis,syn-Cyclobutane Thymine Dimer Lesion. Journal of the American Chemical Society.118 (38),pp 91569163. doi: 10.1021/ja9611304Cooney, Michael G. & Doetsch, P.W. (1994). Molecular modeling Studies of a Deoxyoctanucleotide Containing a Dihydrouridine Lesion. Volume 726, DNA Damage: Effects on DNA Structure and Protein Recognition. Annals of the New York Academy of Sciences, July 1994, pp. 299302. doi: 10.1111/j.PHONE NUMBER AVAILABLEtb52832.xPolinsky, A., Cooney, Michael G., Toy-Palmer, A., Osapay, G., & Goodman, M. (1992). Kahneman, D.Synthesis and conformational properties of the lanthionine-bridged opioid peptide [D-AlaL2,AlaL5] enkephalin as determined by NMR and computer simulations. Journal of Medicinal Chemistry 35 (22), 4185-4194. doi: 10.1021/jm00100a026Candidate's Name , G. Czernuszewicz, E.H. Postel, S. J. Flint and M.E. Hogan.(1988) Site-specific oligonucleotide binding represses transcription of the human c-myc gene in vitro. Science 22 July 1988: Vol. 241 no. 4864, pp. 456-459. doi: 10.1126/science.3293213 |
